About Razani Lab

The Razani laboratory focuses on understanding the mechanisms of common metabolic diseases ATHEROSCLEROSIS

OBESITY

DIABETES 
FATTY LIVER DISEASE

 

We have a particular interest in the following:

Atherosclerotic macrophages

Macrophage polarization

Foam cell formation

Adipose tissue metabolism

Adipose tissue macrophages

Liver metabolism

The autophagy-lysosome system

Lysosomal biogenesis

Lysosomal acidification

Lysosomal acid lipase and lysosomal lipolysis

Selective autophagy (particularly p62/SQSTM1)

Lipophagy

Aggrephagy

Mitophagy

mTOR signaling

Differing roles of mTORC1 and mTORC2

Nanoparticle delivery systems

iPSC (induced pluripotent stem cells)

 

Razani Lab News

  • Trent Evans (graduate student) awarded prestigious NIH NRSA F31 grant in 2016
Lab Mascot:  THE OUROBOROS
  • Represents cyclicality and renewal which are the essence of the autophagy-lysosome system
(designed by Dr. Ismail Sergin - postdoctoral fellow)
  • Ismail Sergin (postdoctoral fellow) chosen for oral presentation at 2016 ATVB meeting
  • Astrid Rodriguez-Velez (summer undergraduate student) wins Outstanding Poster Presentation at 2016 ABRCMS conference
  • Xiangyu Zhang (postdoctoral fellow) wins best poster award at the 2016 Washington University Cardiovascular Research Symposium 
  • Trent Evans (graduate student) selected as 2016 David and Deborah Winston Fellowship in Diabetic Cardiovascular Disease
  • Se-jin Jeong has started in 2017 as our newest Postdoctoral fellow.  Her expertise is in autophagy (particularly lipophagy) and atherosclerosis.
  • Trent Evans (graduate student) selected for 2017 ATVB Travel Award

The Science & 

Mathematics University

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