Razani B and Raines EW. Can the DNA damage response be harnessed to modulate atherosclerotic plaque phenotype?
Recent Journal Publications
- Claude Bernard -
“The joy of discovery is certainly the liveliest that the mind of man can ever feel”
Sergin I, et al. Hypoxia in plaque macrophages: a new danger signal for interleukin-1b activation?
Emanuel R*, Sergin I*, et al. Induction of lysosomal biogenesis in atherosclerotic macrophages can rescue lipid-induced lysosomal dysfunction and downstream sequelae.
Sergin I, et al. Self-eating in the plaque: what macrophage autophagy reveals about atherosclerosis.
Spears L, et al. Interleukins and atherosclerosis: a dysfunctional family grows.
Epelman S, et al. Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation.
Lodhi I, et al. Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARg activation to decrease diet-induced obesity.
Razani B, et al. Autophagy links inflammasomes to atherosclerotic progression
Lei Y, et al. The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy.
Sergin I, et al. Degradation and beyond: the macrophage lysosome as a nexus for nutrient sensing and processing in atherosclerosis
Sergin I, et al. Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis
Evans TD, et al. Modulating oxysterol sensing to control macrophage apoptosis and atherosclerosis.
Leng S, et al. Ursolic acid enhances macropahge autophagy and attenuates atherogenesis.
Block RC and Razani B. Options to consider when treating lysosomal acid lipase deficiency.
Lee Y, et al. Keap1/Cullin3 modulates p62/SQSTM1 activity via UBA domain ubiquitination.
Evans TD, et al. Target acquired: Selective autophagy in cardiometabolic disease.
Lanza GM, et al. Anti-angiogenic nanotherapy inhibits airway remodeling and hyper-responsiveness of dust mite triggered asthma in the Brown Norway rat.